New Arsenal centre back Thomas Vermaelen is set to start for Arsene Wenger's side, while Everton have a number of key players sidelined.
Definitely out for David Moyes side are strikers Yakubu, Victor Anichebe; defender Phil Jagielka and midfielder Mikel Arteta.
Also rated doubtful is Steven Pienaar, who has a knee problem. Leon Osman looks the likely replacement if the South African doesn't make it.
Loan signing Jo is fit, despite an ankle injury and could start upfront on his own, with fellow striker Louis Saha on the bench.
Arsenal too have injury concerns, with Theo Walcott, Abou Diaby, Johan Djourou and Samir Nasri joining long term absentee Tomas Rosicky.
Emmanuel Eboue may get a run out on the right of midfield, with Alex Song coming into the centre. Robin Van Persie will start upfront on his own.
KICK-OFF: SATURDAY AUGUST 15th 17:30 GMT
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