Chelsea will be without suspended goalkeeper Petr Cech, while midfielder Javier Mascherano returns to the Liverpool squad.
Cech will be replaced between the sticks by Hilario, who also played in Chelsea's midweek Champions League victory.
Returning from suspension is Didier Drogba, who will start alongside Nicolas Anelka; and right back Jose Bosingwa.
Rated doubtful for Carlo Ancelotti's Chelsea are the trio of Alex, Michael Ballack and Daniel Sturridge.
However, Joe Cole is fit after a long absence, but is set for a place on the bench, with Florent Malouda continuing on the left side of midfield.
Liverpool midfielder Javier Mascherano has overcome a hamstring problem and is set to start for Rafa Benitez' side.
If the Argentine does make it, Fabio Aurelio will drop to the bench.
Defender Daniel Agger is back in training, but is unlikely to supplant Liverpool's first choice central defensive partnership of Jamie Carragher and Martin Skrtel.
Despite scoring two goals in Liverpool's 6-1 victory over Hull, Ryan Babel is set for a place on the bench, with Yossi Benayoun preferred in midfield to the Dutchman.
KICK-OFF : SUNDAY OCTOBER 4th 16:00 GMT
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