Fernando Torres and Steven Gerrard are missing for a Liverpool side, while ex-Liverpool midfielder Bolo Zenden could start for Steve Bruce's Sunderland side.
Zenden, who signed a year long deal with Sunderland in midweek, could come in as left back in place of the suspended Kieran Richardson, although George McCartney would be in contention if he overcomes a foot problem.
Sunderland boss Steve Bruce will run the rule over Trinidad and Tobago striker Kenwyne Jones, who was on international duty during the week. If Jones isn't sufficiently match fit, Fraizer Campbell will partner Darren Bent in attack.
For Liverpool boss Rafa Benitez, injuries to both Torres and Gerrard has caused a problem.
Ryan Babel could start in support of Dirk Kuyt, who will playing a more advanced role in Torres' absence.
Defender Daniel Agger is back in contention and could start in a three man defence.
Liverpool boss Benitez will assess South American trio Javier Mascherano, Emiliano Insua and Lucas after they return from their midweek World Cup Qualifiers.
Definitely out, however, is Greek international Sotirios Kyrgiako, who has sustained a serious knee injury.? Jamie Carragher and Martin Skrtel are the most likely central defensive partnership.
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