Despite having already qualified, England manager Fabio Capello has stressed he will pick a strong line-up for this World Cup qualifier away to the Ukraine.
Although keeper David James has been recalled to the England squad, it is thought that West Ham's Robert Green will continue in goal after some capable performances.
Elsewhere, England boss Capello looks likely to give the nod to Emile Heskey and Wayne Rooney as a starting strike partnership, with Carlton Cole and Gabriel Agbonlahor named among the substitutes.
In defence, Rio Ferdinand will partner John Terry, with West Ham's Matthew Upson dropping to the bench.
The midfield could see Manchester United midfielder Michael Carrick replacing Gareth Barry, with Aaron Lennon retaining his place on the right of midfield.
Ukraine head coach Alexei Mikhailichenko has a number of defensive injury concerns. Both Dmytro Chygrynskiy and Andriy Rusol are sidelined, while a third defender - Vitaliy Manziuk - is suspended so Taras Mykhalyk gets a recall to the squad.
With five goals in qualifying so far, Andriy Shevchenko is again set to start as Ukraine captain, supported by either Andriy Voronin or Yevhen Seleznyov of Dnipro Dnipropetrovsk, at whose ground this match takes place.
KICK-OFF: SATURDAY OCTOBER 10th 17:15 GMT
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