Central defenders Rio Ferdinand and Nemanja Vidic are both doubtful for Sir Alex Ferguson's Manchester United side, while Blackburn defender Christophe Samba is still sidelined with swine flu.
Both Ferdinand and Vidic are suffering with calf injuries, so Wes Brown and Johnny Evans may start.
Definitely out for United are midfielders Park Ji-Sung and Darren Fletcher, striker Danny Wellbeck and the suspended Gary Neville; while Ryan Giggs is a doubt.
Nani and Anderson may both start in midfield, with Michael Owen replacing Dimitar Berbatov as the strike partner to Wayne Rooney.
With Samba and Pascal Chimbonda both out, Blackburn Rovers boss Sam Allardyce may hand veteran Michel Salgado another start in defence.
Striker Jason Roberts looks the latest Blackburn player to have succumbed to swine flu, so Franco Di Santo looks set to start upfront alone.
However, fellow swine flu victim David Dunn has overcome the illness and is in contention to start against United.
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