Arsenal have Alex Song and Eduardo back in contention, while Manchester City are hopeful that Micah Richards will be fit enough to play some part.
Richards has a toe injury, but will face a late fitness test. If fit, he will be on the bench, with Nedum Onuoha preferred at right back.
Ex-Arsenal striker Emmanuel Adebayor is expected to start upfront, in tandem with Carlos Tevez.
Two other former Arsenal players, Kolo Toure and Patrick Vieira are also expected to be in the Manchester City squad, with Vieira starting on the bench.
With Denilson out, the return of Alex Song from cartilege problems is timely. If sufficiently fit, Song will start in place of youngster Craig Eastwood.
With Thomas Vermaelen still out, veterans Silvestre and Sol Campbell will start at centre back.
Also absent for Arsene Wenger's Arsenal side are Cesc Fabregas, Andrey Arshavin , Johan Djourou (knee), William Gallas and Kieran Gibbs.
However, fit again Robin Van Persie could start in place of Nicklas Bendtner.
KICK-OFF: SATURDAY APRIL 24th 17:30 GMT
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