John Terry is suspended for Chelsea and will be replaced by Bratislav Ivanovic in central defence.
The fit again Ashley Cole could replace Yuri Zhirkov at left back and - with both Michael Essien and Jon Mikel Obi out - Michael Ballack will return to the centre of midfield.
Deco is also likely to start for Carlo Ancelotti's side, with Joe Cole having to be content with a place on the bench.
Didier Drogba has persistent minor niggles in the last few weeks, but is expected to start alongside Nicolas Anelka.
Stoke manager Tony Pulis welcomes back a number of key players to the squad, including defender Ryan Shawcross, who has overcome an ankle injury, and winger Matthew Etherington, who has recovered from a knock to the knee.
Also back in contention for a start is striker RIcardo Fuller, who was a substitute last time out, having suffered an ankle injury in the match with Hull City.
Definitely out, however, is fellow striker Mamady SIdibe, who has a groin strain.
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